超级扫描在第一个治疗后的177 Lu-PSMA扫描中
Merve Nida Calderon Tobar1, Farise Yilmaz, Lütfü Perktaş
1From the, Department of Nuclear Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey.
Clinical nuclear medicine
|December 4, 2024
概括
177 Lu-PSMA疗法有效地治疗了一名患有晚期前列腺癌和广泛骨转移的70岁男性. 治疗后的扫描证实了完整的反应,显示了骨病变的消失和正常的器官吸收.
科学领域:
- 核医学是一种核医学.
- 在瘤学瘤学.
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 前列腺癌可以发展为抵抗割的前列腺癌 (CRPC).
- 广泛的骨转移是晚期CRPC的常见并发症.
- 177 Lu-PSMA-617有针对性的放射性核酸治疗提供了一种新的治疗方法.
研究的目的:
- 为了评估177Lu-PSMA-617治疗在转移性CRPC患者中的有效性.
- 通过治疗后全身成像来评估治疗反应.
主要方法:
- 一名70岁的男性患者患有CRPC和广泛的骨转移,接受了4个周期的177次Lu-PSMA-617治疗.
- 在第一和第四个周期后,进行了177次全身Lu-PSMA扫描.
- 根据骨损伤吸收和器官吸收的变化来评估反应,使用RECIP 1.0标准.
主要成果:
- 循环1后的初始扫描显示了扩散的骨病变,脏和唾液腺的吸收量最小.
- 第四个周期后的扫描显示了骨转移的完全解决.
- 在4个循环后,脏和唾液腺体的PSMA吸收正常.
- 根据RECIP 1.0标准,患者实现了完全反应.
结论:
- 177 Lu-PSMA-617疗法在管理CRPC中广泛的骨转移方面非常有效.
- 向放射性核酸治疗可以导致转移性疾病的完全缓解.
- 这种方法证明了治疗后正常器官吸收的良好安全性.
相关概念视频
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
83
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
83
01:29Positron Emission Tomography
4.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.0K
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
86
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
86