在极端山地超级马拉松之后加速红细胞周转率?
Bastien Krumm, Antoine Raberin1, Tom Citherlet1
1Institute of Sport Sciences, University of Lausanne, Lausanne, SWITZERLAND.
Medicine and science in sports and exercise
|December 4, 2024
概括
极端的山地超级马拉松会增加血体积和炎症,但保持血红蛋白质量. 红细胞循环的增强,可能是由于轻微的血液溶解,以加速的红色素形成为平衡,在长时间的耐力事件后发生.
科学领域:
- 运动医学 运动医学
- 运动生理学 运动生理学
- 血液学 血液学 血液学
背景情况:
- 山地超级马拉松 (MUM) 给人带来极端的生理压力.
- 血液溶解和随后的血红蛋白质量 (Hbmass) 减少是MUM的可疑后果.
- 在330公里MUM后的血液学变化以前没有被研究过.
研究的目的:
- 为了研究血液学变化,包括血液体积,粘度,以及炎症,红色受体和血液溶解的生物标志物,在330公里的MUM之后.
- 为了确定极端耐力运动对红细胞动态的影响.
主要方法:
- 在13名参与者中,使用一氧化碳 (CO) 重呼吸方法测量了赛前和赛后的血量.
- 血液粘度在各种剪切速率下使用圆板粘度计进行评估.
- 对炎症的生物标志物 (介质素-6,C-反应蛋白),红色素生成 (红色素,红) 和血液溶解进行了量化.
主要成果:
- 赛后血体积增加了18% (P = 0.001),而绝对Hb质量没有显著变化 (P = 0.09).
- 在所有测试速度下,血液粘度显著下降 (P < 0.001).
- 显著的炎症是由高的互白素-6和C反应性蛋白水平表明的. 红色素和红色的增加表明红色素生成的增强.
结论:
- 一个330公里的MUM导致血体积增加和炎症.
- 尽管有潜在的运动诱导的血液溶解,血红蛋白质量是保持,可能通过加速的红细胞生成.
- 这些发现表明,红细胞在应对极端耐力运动时会有动态的循环.
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