患有帕金森病和深度大脑刺激的患者的白细胞性脑病
Pawel Jarski1, Turab Gasimov1, Cristina Dragaescu2
1Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany.
Movement disorders clinical practice
|December 4, 2024
概括
在接受深度大脑刺激 (DBS) 的帕金森病 (PD) 患者中,轻度至中度的白脑病变 (LE) 不会增加手术风险或阻碍运动功能的改善. 在PD患者中,LE不应禁忌进行DBS手术.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 医疗成像医学成像
背景情况:
- 白脑病变 (LE) 是老年人的MRI常见发现.
- 在LE中白质病变可以使帕金森病 (PD) 患者的深度大脑刺激 (DBS) 位复杂化.
- 在DBS手术后,LE与不良结果有关.
研究的目的:
- 为了确定在接受DBS的PD患者中LE的发病率.
- 评估LE和DBS后的术后并发症之间的相关性.
- 评估LE对PD患者的DBS疗效的影响.
主要方法:
- 连续一组接受了亚thalamic核DBS (STN-DBS) 的PD患者的回顾性分析.
- 使用Fazekas尺度量化LE的量化.
- 使用统一帕金森病评分表 (UPDRS III) 抽取术后并发症和评估DBS在1年随访后的疗效.
主要成果:
- 在135名PD患者中,LE在35.6%的患者中存在,主要是轻度至中度.
- 在轻度至中度LE和术后出血或感染风险增加之间没有发现相关性.
- LE与刺激效率或外科指数没有相关性.
结论:
- 轻度至中度LE与PD患者的DBS后手术并发症风险增加无关.
- 轻度至中度LE的存在不会对DBS后的长期运动功能的改善产生负面影响.
- 轻度至中度的LE不应被认为是PD患者DBS手术的禁忌.
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