在接受免疫疗法加贝瓦西祖马布治疗的肝细胞癌患者的伪进展
Sebastián Díaz López1, Carlota Jimeno Maté2, Eva María Fernández Parra1
1Hepatic Oncology , Hospital Nuestra Señora de Valme, Spain.
Revista espanola de enfermedades digestivas
|December 4, 2024
概括
肝细胞癌与阿特佐利祖马布加贝瓦齐祖马布的治疗初始显示超进展,但后来揭示了肺转移的完整反应和肝转移的部分反应,表明伪进展.
科学领域:
- 在瘤学瘤学.
- 肝细胞癌研究 肝细胞癌研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 肝细胞癌 (HCC) 是一种主要的肝癌,具有显著的全球健康影响.
- 手术切除是早期HCC的主要治疗方法.
- 先进的HCC通常需要全身治疗,包括免疫疗法.
研究的目的:
- 报告一个先进的肝细胞癌的病例,用阿特佐利祖马布加贝瓦西祖马布治疗.
- 为了调查疑似伪进展的患者的临床过程和治疗反应.
- 强调在HCC治疗中区分真实进展和伪进展的重要性.
主要方法:
- 一名62岁的HCC男性接受了手术,后来出现了转移性疾病.
- 治疗开始用阿特佐利祖马布加贝瓦齐祖马布治疗肝脏和肺部转移.
- 在整个治疗过程中,放射学和血清学标志物 (α-fetoprotein) 被监测.
主要成果:
- 在四个周期后的初始CT扫描显示肝脏和肺转移的超级进展.
- 患者报告说,腹部疼痛改善,阿尔法-胎蛋白水平降低,这表明伪进展.
- 2个月后的随访CT扫描显示了肺转移的完整反应和肝转移的部分反应.
结论:
- 阿特佐利祖马布加贝瓦齐祖马布可以导致晚期HCC的复杂治疗反应.
- 区分伪进展和真正的瘤进展对于最佳的患者管理至关重要.
- 尽管出现了进展的最初迹象,但继续治疗可能会在特定的HCC病例中带来有利的结果.
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