青少年患有抗NMDA受体脑炎 (catatonia) 的替代治疗方法
Abhishek Wadhwa1, Carol Vidal2,3, Yasmina Saade4
1Division of Child and Adolescent Psychiatry, Department of Psychiatry & Behavioral Neurobiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Neurocase
|December 4, 2024
概括
在标准治疗失败后,Zolpidem有效地治疗了患有抗N-甲基-D-酸盐受体脑炎 (ANMDAE) 的青少年的白内障. 这表明佐洛皮德姆是治疗耐火儿科白内障的潜在替代品.
科学领域:
- 神经免疫学 神经免疫学
- 儿科神经学 儿科神经学
- 精神病学是一个精神病学.
背景情况:
- 抗N-甲基D-酸盐受体脑炎 (ANMDAE) 是一种免疫媒介疾病,具有多种神经精神症状,包括.
- 卡塔托尼是一种严重的精神运动障碍,具有重大医疗风险,需要及时管理.
- 目前的指导方针推使用类药物和电疗法 (ECT) 治疗白内障,但疗效在儿科患者群体中有所不同,特别是ANMDAE.
研究的目的:
- 报告一例成功的索尔皮德姆治疗青少年患有ANMDAE的白内障的案例.
- 突出在儿童ANMDAE病例中管理耐火性白内障的挑战.
- 在一线治疗方法不足时,探索佐洛皮作为潜在的治疗选择.
主要方法:
- 一名患有ANMDAE和catatonia的12岁青少年接受了佐洛比.
- 这种治疗是在未能对二类药物和ECT产生反应或耐受之后开始的.
- 在使用佐洛皮德姆后评估了临床结果.
主要成果:
- 这名青少年患者对 Catatonia. zolpidem 治疗表现出成功的反应.
- 这一案例证明了佐洛皮德姆在标准的白内障治疗无效的情况下的疗效.
- 这些发现有助于在ANMDAE的青少年中使用索尔皮治疗白内障的有限文献.
结论:
- 早期识别和管理ANMDAE与catatonia是至关重要的.
- 需要扩大治疗指南,用于对标准疗法耐药的儿科白内障.
- 索尔皮德姆为接受ANMDAE的青少年提供了可行的替代治疗方法,这些青少年对二类药物或ECT无反应或无法耐受.
相关概念视频
Antiepileptic Drugs: Glutamate Antagonists
281
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
281
Electroconvulsive Therapy
25
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
25
Skeletal Muscle Relaxants: Therapeutic Uses
463
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
463
Mania and Antimanic Drugs: Overview
135
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
135
Parkinson's Disease: Treatment
219
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
219
Anticholinesterase Agents: Poisoning and Treatment
790
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
790


