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αC-β4循环在蛋白激酶结构和动态中的作用

Jian Wu1, Nisha A Jonniya1, Sophia P Hirakis2

  • 1Department of Pharmacology, University of California, San Diego, San Diego, United States.

eLife
|December 4, 2024
PubMed
概括

蛋白激酶中的αC-β4循环对于维持疏水性核心结构和叶片通信至关重要. 突变会破坏这种相互作用,影响ATP结合和激酶功能.

关键词:
在F100A突变病毒中.当地的空间模式.分子生物物理学分子生物物理学分子动力学模拟,分子动力学模拟没有,没有,没有.蛋白质激酶A是一种蛋白质激酶.结构生物学结构生物学在αC-β4循环中,

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