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根据一项全国性队列研究中填写的处方序列,抗抑郁药可接受性的性别差异
Charles Ouazana Vedrines1,2,3, Nicolas Hoertel4,5, Thomas Lesuffleur6
1Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and Statistics (CRESS), Paris, France.
The Journal of clinical psychiatry
|December 4, 2024
概括
这项研究发现,抗抑郁药可接受性的性别差异. 对于女性来说,素更容易被接受,而对于男性来说,帕罗素更容易被接受,从而为个性化治疗策略提供了信息.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 现实世界的证据.
背景情况:
- 抑郁症和焦虑症在女性中更为普遍.
- 关于抗抑郁药有效性的性别相关差异的证据是不确定的.
- 需要实践研究来评估药物的性别可接受性.
研究的目的:
- 为了比较女性和男性之间的抗抑郁药物的临床可接受性.
- 分析抗抑郁药物的有效性和耐受性的性别特异性.
- 为临床实践和政策提供有关抗抑郁药物选择的信息.
主要方法:
- 分析了来自法国国家健康数据系统 (Système National des Données de Santé [SNDS]) 的120万新抗抑郁药使用者的全国队列.
- 临床可接受性是通过在一线治疗处方后6个月的持续/变化比来衡量的.
- 使用多变量二元逻辑回归计算调整的几率比率 (aOR),考虑药物补充和切换.
主要成果:
- 总的来说,抗抑郁药的可接受性在女性中略高于男性 (aOR,1.06 [1.05-1.08]).
- 埃斯基塔洛普拉姆在两性中都表现出很高的可接受性.
- 对素 (在女性中更可接受) 和帕洛素 (在男性中更可接受) 观察到显著的性别药物相互作用.
结论:
- 现实世界的数据显示,抗抑郁药可接受度的性别特异性差异.
- 素和帕洛素显示出基于性别的不同可接受性.
- 这些发现可以指导从业者和政策制定者优化女性和男性抗抑郁药物选择.
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