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Updated: Jun 5, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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Published on: November 9, 2020

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作为目标蛋白质降解策略的Aptamer和N-Degron合并 (AptaGron)

Mohammad Faysal Al Mazid1,2, Olha Shkel3,2, Eunteg Ryu2

  • 1Division of Bio-Medical Science and Technology, Korea Institute of Science and Technology (KIST) & Department of Biological Chemistry, KIST School UST, Seoul 02792, South Korea.

ACS chemical biology
|December 4, 2024
PubMed
概括

一个新的AptaGron系统使用aptamers进行向蛋白质降解,克服了寻找特定配体的挑战. 这种方法成功地降解了,核素和eIF4E蛋白质,而无需化学结合.

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