相关实验视频

Updated: Jun 5, 2025

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

阻塞性睡眠呼吸暂停对外围血液单核细胞的性别特异性影响

Joshua M Bock¹, Soumya Vungarala¹, Sreeja Sompalli¹

¹Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55901, USA.

Sleep & breathing = Schlaf & Atmung

|December 4, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 改变女性免疫细胞,增加细胞毒性自然杀手 (NK) 细胞和调节性T细胞 (Tregs). 在患有OSA的男性中没有观察到这些变化,这表明性别特异的免疫反应.

科学领域:

免疫学免疫学免疫学
睡眠医学睡眠医学
健康中的性别差异

背景情况:

实验性睡眠障碍对免疫功能产生负面影响,女性的免疫功能比男性更强.
目前尚不清楚这种性别特异性免疫反应是否延伸到阻塞性睡眠呼吸暂停 (OSA) 患者.

研究的目的:

为了研究未经治疗的OSA患者的外周血液单核细胞 (PBMC) 的性别差异.
为了确定OSA是否在男性和女性之间不同地影响免疫细胞群.

主要方法:

参与者接受了睡眠研究,以使用呼吸暂停-呼吸暂停指数 (AHI) 来诊断OSA.
周围血液单核细胞 (PBMC) 被分离,冷保存,并使用质细胞计分析.
免疫细胞种群包括T细胞,B细胞,单细胞,粒细胞,NK细胞和Tregs被量化.

主要成果:

对于CD3 T细胞,CD8 T细胞,B细胞,单细胞或粒细胞,没有发现显著的群体性相互作用.
与没有OSA的女性相比,患有OSA的女性显示CD57+ (细胞毒性) NK细胞的百分比较高,CD57-NK细胞的百分比较低.
调节性T细胞 (Tregs) 在患有OSA的女性中明显比在没有OSA的女性中更为普遍.
在患有和没有OSA的男性之间,没有观察到NK细胞子集或Tregs的显著差异.

结论:

阻塞性睡眠呼吸暂停 (OSA) 似乎增加了细胞毒性NK细胞和Tregs的患病率,特别是在女性中.
在OSA中,这些性别特异性免疫变化的潜在机制和临床影响需要进一步研究.

关键词:

氧气过低是因为缺氧.自然杀手细胞是什么?监管T细胞监管T细胞睡眠呼吸暂停 (Sleep Apnea) 是一种疾病.

更多相关视频

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

相关概念视频

Sleep Apnea

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.