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控制pH的酸的短暂循环,以提高稳定性,使其更容易通过口服输送

Maciej P Paprocki1,2, Kasper K Sørensen1, Knud J Jensen1

  • 1Department of Chemistry, University of Copenhagen, DK-1871, Frederiksberg, Denmark.

Chemistry (Weinheim an der Bergstrasse, Germany)
|December 4, 2024
PubMed
概括

新的化学方法通过保护胃中的来实现口服的输送. 这种pH响应的线性化策略增强了的稳定性和生物可用性,用于潜在的治疗应用.

关键词:
循环类酸是一种循环类酸.这是口头交付的交付.类药物化学 类药物化学

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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