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辅助高压氧疗法和负压伤口治疗难以愈合的伤口:一个系统的审查和元分析

Liehao Yang¹, Jiao Kong¹, Yunlong Xing¹

¹Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, China.

Journal of wound care

|December 4, 2024

概括

将负压伤口疗法 (NPWT) 与高压氧疗法 (HBOT) 结合起来,可显著提高愈合率,并降低慢性伤口中的细菌负载. 这种综合方法为难以愈合的伤口提供了安全有效的治疗选择.

科学领域:

伤口愈合研究研究研究
再生医学是一种再生医学.
临床疗效研究临床疗效研究

背景情况:

负压伤口疗法 (NPWT) 和高压氧疗法 (HBOT) 是慢性伤口的既定治疗方法.
对NPWT和HBOT在难以愈合的伤口中的联合疗效的证据仍然有限.
需要进行系统性审查,以评估NPWT辅助HBOT的临床益处和安全性.

研究的目的:

系统地审查和元分析加高压氧疗法 (HBOT) 与负压伤口疗法 (NPWT) 的临床疗效和安全性,用于难以愈合的伤口.
评估NPWT和HBOT联合治疗对关键伤口愈合参数的影响.

主要方法:

在Embase,PubMed,Cochrane图书馆,Web of Science,CNKI和万芳数据库中进行全面的文献搜索,截至2022年3月.
包括随机临床试验和回顾性研究,使用Cochrane风险偏差工具和纽卡斯尔-太华尺度进行质量评估.
使用R编程软件进行的元分析,遵循PRISMA 2020指南.

主要成果:

结合NPWT和HBOT,与单独NPWT相比,明显提高了伤口愈合率 (OR=6.77),减少了细菌负载 (OR=0.16),并缩短了愈合时间 (MD=-3.86天).
在伤口面积减少 (SMD=1.50),减少住院时间 (MD=-3.14天) 和减少住院费用 (OR=-202.64) 中观察到显著改善.
治疗组之间的疼痛评分没有显著差异 (MD=-0.43).

结论:

附加的高压氧气疗法 (HBOT) 与负压伤口疗法 (NPWT) 是治疗难以愈合的伤口的安全有效策略.
结合疗法在加速伤口关闭和改善患者结果方面显示出显著的好处.
由于包含的研究中固有的局限性,研究结果应谨慎解释.

关键词:

慢性伤口慢性伤口高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.这是一个元分析.负压伤口治疗负压伤口治疗系统性审查系统性审查伤口的伤口是伤口.伤口护理伤口护理伤口上使用了伤口带.伤口愈合伤口愈合

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