未成熟粒细胞在急性复杂尾炎的预测疗效
Merve Yazla1, Burcu Kadıoğlu1, Hacer Demirdelen1
1Ankara Etlik City Hospital, Emergency Medicine - Ankara, Turkey.
Revista da Associacao Medica Brasileira (1992)
|December 4, 2024
概括
不成熟的颗粒细胞百分比可以帮助诊断复杂的尾炎. 这种生物标志物比其他炎症标志物具有较高的特异性和更好的歧视性.
科学领域:
- 紧急医疗 紧急医疗
- 临床病理学 临床病理学
- 炎症生物标志物 炎症生物标志物
背景情况:
- 急性尾炎是急性腹部的常见原因,需要及时诊断.
- 在手术前区分复杂和非复杂的尾炎对于患者的管理至关重要.
- 不成熟的粒细胞正在成为潜在的炎症指标.
研究的目的:
- 评估不成熟粒细胞水平作为复杂急性尾炎的预测生物标志物.
- 评估不成熟粒细胞在急诊室患有尾炎的患者的诊断效用.
主要方法:
- 一项队列研究,包括2023年5月至2024年4月期间被诊断患有尾炎的成年患者.
- 患者被分为无并发症 (n=149) 和并发症 (n=103) 尾炎组,根据他的病理学.
- 分析了人口统计,成像和实验室数据,包括不成熟的粒细胞数量和百分比.
主要成果:
- 在复杂尾炎组中观察到明显升高的白细胞,中性粒细胞,淋巴细胞和不成熟的粒细胞水平.
- 未成熟颗粒细胞百分比显示出92%的特异性复杂尾炎的切断值为0.6.6.
- 不成熟颗粒细胞的百分比比较于不成熟颗粒细胞数量,C-反应蛋白和prokalcitonin,显示出更高的分辨力.
结论:
- 未成熟的粒细胞百分比是诊断复杂急性尾炎的有希望的生物标志物.
- 这种生物标志物比其他炎症标志物具有较高的特异性和优越的预测价值.
- 这些发现支持将不成熟颗粒细胞评估纳入急诊室的尾炎评估.
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