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来自Dinizia excelsa的西兰:化学表征和生物活动

Ila M Oliveira¹, Sônia P Leite², Amanda Rafaela C Mesquita³

¹Universidade Federal de Pernambuco (UFPE), Centro de Biociências, Departamento de Antibióticos, Av. Professor Moraes Rego, s/n, Cidade Universitária, 50740-600 Recife, PE, Brazil.

Anais da Academia Brasileira de Ciencias

|December 4, 2024

概括

从Dinizia excelsa木材中提取的西兰显示出有前途的免疫调节和抗凝固特性. 这种亚马逊树的衍生物具有较低的毒性,这表明了潜在的生物医学应用.

科学领域:

生物化学生物化学
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

亚马逊树Dinizia excelsa是一种有价值的工业原料.
克西兰是一种多糖,在植物细胞壁中丰富,具有多样化的应用.

研究的目的:

为了从Dinizia excelsa木中提取和表征西兰.
为了评估提取的西兰的生物活性.

主要方法:

克西兰的提取涉及脱,沉,净化和冷干燥.
物理化学表征包括单糖体分析,元素组成,FTIR,2D NMR和分子量测定.
评估的生物活性包括细胞毒性,免疫调节作用,抗凝活动和抗氧化能力.

主要成果:

提取得到了具有特定元素组成的28.44%西兰 (35.03%C,5.65%H,59.32%O).
FTIR和2DNMR证实了Dinizia excelsa xylan的结构,显示了与商用xylan的相似性.
克西兰表现出低细胞毒性,显著的免疫调节活性 (刺激细胞增殖和抗炎性细胞因子的产生),低抗凝剂活性和较弱的抗氧化活性.

结论:

迪尼西亚优秀的西兰具有有利的物理化学特性和低毒性.
提取的西兰具有显著的免疫调节和抗凝剂潜力,可用于生物医学应用.

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