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Updated: Jun 5, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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酸4,5-双酸驱动EGFR和EphA2复合物的形成

Pradeep Kumar Singh1, Jennifer A Rybak2, Ryan J Schuck3

  • 1Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79410, USA.

Science advances
|December 4, 2024
PubMed
概括

在活细胞中表皮生长因子受体 (EGFR) 和以素受体A2 (EphA2) 的相互作用通过PIE-FCCS得到解决. 固醇4,5-双酸盐 (PIP2) 水平显著影响了受体组织和二分化.

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