围产期睡眠质量的变化与非典型的皮质醇唤醒反应和情绪症状增加有关
Michele L Okun1, Suzanne Segerstrom2, Susan Jackman3
1University of Colorado, Colorado Springs, USA.
Psychoneuroendocrinology
|December 4, 2024
概括
怀孕期间的睡眠质量影响皮质醇唤醒反应 (CAR) 的变化,而不是整体水平. 睡眠质量差与产后抑郁症和焦虑症的增加相关,但皮质醇不会调解这种联系.
科学领域:
- 围产期心理健康 围产期心理健康
- 内分泌学 在内分泌学.
- 睡眠科学 睡眠科学
背景情况:
- 在怀孕和产后期间,睡眠质量往往会下降.
- HPA轴调节失调和皮质醇升高与不良妊娠结果有关.
- 皮质醇唤醒反应 (CAR) 在整个怀孕期间发生变化.
研究的目的:
- 为了检查睡眠质量和皮质醇水平在围产期之间的关系.
- 为了确定睡眠质量是否预测产后情绪.
- 为了研究皮质醇在睡眠情绪关联中的调解作用.
主要方法:
- 利用了健康婴儿出生前 (HB3) 研究的数据 (N=223).
- 在四个围产期时间点评估睡眠质量 (PSQI),情绪症状和唾液皮质醇.
- 采用多层模型来分析皮质醇指数 (CAR,日间斜率,AUC) 和情绪结果.
主要成果:
- 睡眠质量与整体皮质醇指数或随时间变化的变化无关.
- 睡眠质量的变化增加 (更高的PSQI得分) 与更的CAR斜率有关.
- 较差的睡眠质量与较高的抑郁和焦虑症状严重程度有显著的相关性.
结论:
- 睡眠质量的变化,而不是睡眠质量的平均值,与CAR的变化有关.
- 没有发现睡眠质量与皮质醇白天倾斜或AUC之间的联系.
- 皮质醇没有调解睡眠质量和产后抑郁症症状之间的联系.
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