聚乙烯微塑料暴露会调节黄金头海 (Sparus aurata) 的肠道微生物群和肠肝轴
Filomena Del Piano1, Baptiste Mateu2, Lorena Coretti2
1Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
The Science of the total environment
|December 4, 2024
概括
聚烯微塑料 (MPs) 破坏了黄金头海的肠道微生物群和肝脏免疫力. 这项研究揭示了MPs改变肠道细菌,增加肝炎,并影响胆酸代谢,突出了肠肝轴毒性.
科学领域:
- 环境毒理学环境毒理学
- 水生生态学 水生生态学
- 微生物学 微生物学
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,影响生态系统.
- 肠肝轴是关键的通讯通道,容易受到环境影响.
- 关于MPs对肠肝轴的影响的研究有限.
研究的目的:
- 为了研究饮食中的聚烯微塑料 (PS-MPs) 对金头海 (Sparus aurata) 的肠肝轴的影响.
- 评估肠道微生物群组成和功能的变化.
- 评估对肝脏免疫反应和胆酸代谢的影响.
主要方法:
- 在21天的时间里,Gilthead海被养以不同度的PS-MPs (0.25或250毫克/公斤/天) 的饮食.
- 分析了肠道微生物群的组成.
- 在肝脏中量化了免疫媒介和胆酸代谢标记物的基因表达.
主要成果:
- PS-MPs改变了肠道微生物群,增加了物种均性,但降低了核心微生物群的稳定性和减少了有益细菌.
- 免疫和炎症媒介 (TLR2,TLR5,COX-2) 的肝脏基因表达增加.
- 血清甘油三和胆汁酸 (BAs) 升高,肝脏BA代谢基因表达变化 (CYP27A1,LXRa) 和预测微生物BA代谢功能.
结论:
- 摄入的PS-MPs破坏了金头海的肠道微生物群结构和功能.
- PS-MPs诱导肝脏天生的免疫激活并改变胆酸代谢.
- 这些发现表明,肠肝轴在微塑料诱导的毒性中起着重要作用.
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