脚手架几何学的影响3D打印的多乳酸骨架脚手架的降解率
Nazanin Khaki1, Emad Sharifi2, Mehran Solati-Hashjin2
1Department of Bioengineering, College of Engineering, University of Illinois at Chicago, Chicago, IL, USA.
Journal of biomaterials applications
|December 4, 2024
概括
研究了具有不同几何形状的3D打印多乳酸支架的降解性和适用于组织工程的适用性. 六角架构降解得更快,而格子架构显示出最高的细胞附着和活力,表明骨再生的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 3D打印技术的发展
背景情况:
- 组织工程 (TE) 使用3D打印来制造模仿骨结构的支架,用于替代应用.
- 脚手架微环境必须支持细胞粘附,增殖,分化和迁移.
- 控制聚乳酸 (PLA) 支架的降解速度对于匹配目标组织再生至关重要.
研究的目的:
- 为了研究不同几何形状的3D打印PLA支架的降解行为.
- 为了确定脚手架的几何形状与其降解率之间的关系.
- 为了评估机械性能和在体外细胞反应的选择脚手架的几何形状.
主要方法:
- 有五种不同的几何形状的PLA脚手架是使用化沉积模型 (3D打印) 制造的.
- 支架被浸泡在酸性介质 (pH2) 中两个月,测量重量,形态,分子量和结晶度.
- 机械性质和细胞附着/活力 (晶格,六角形,轮回形) 在体外进行了评估.
主要成果:
- 波形几何形状 (六角形,旋转形) 显示出更高的流体持有能力.
- 六角形几何学显示由于增加表面积和酸透而加速降解.
- 六角支架的弹性模量最高 (105 MPa),而旋转支架的弹性模量最低 (58.8 MPa).
- 格子支架在72小时内表现出最高的细胞附着和活力.
结论:
- 脚手架的几何结构显著影响降解速度和液体保留.
- 在某些几何形状下分离的光纤通过增加表面积和酸透增加了降解.
- 评估的3D打印PLA支架,特别是格子几何学,显示出促进组织工程应用中细胞生长的前景.
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