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在人类大脑中,单色素纤维概况和核素组位置映射

Cyril J Peter1, Aman Agarwal2, Risa Watanabe3

  • 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cell reports methods
|December 4, 2024
PubMed
概括

单分子色氨酸纤维测序 (Fiber-seq) 绘制了人类大脑细胞中的基因调控元素. 这种方法在高分辨率下揭示了细胞特异性的染色质结构和调节模式.

关键词:
CP: 生物技术 生物技术科普:神经科学是什么意思甲基转移酶Hia5 的作用.亚丁胺甲基化 亚丁胺甲基化细胞因子甲基化.长时间阅读序列排序.一个核组的核组.核酶体偏移的抵消尸体死后大脑的研究结果转录因子足迹是指转录因子的足迹.

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
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