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高血血红素水平与缺血性中风后认知障碍风险降低有关

Yu He¹, Xinyue Chang¹, Yi Liu¹

¹Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province 215123, PR China.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|December 4, 2024

概括

高血血栓素水平与缺血性中风患者中,中风后认知障碍 (PSCI) 的风险较低有关. 这表明,血栓模块素可以作为预测和潜在治疗PSCI的生物标志物.

科学领域:

神经科学是一个神经科学.
心血管医学心血管医学
生物化学生物化学

背景情况:

血栓模块素是一种具有已知的抗凝固,抗炎和细胞保护功能的血栓受体.
它在缺血性中风中的作用是公认的,但它与中风后认知障碍 (PSCI) 的关联尚未得到充分理解.

研究的目的:

为了前性地研究血血栓模块素水平与患有缺血性中风的患者PSCI风险之间的关联.

主要方法:

一项多中心队列研究包括615名缺血性中风患者.
在基线测量了血血栓模块素水平.
在3个月的随访期间,用蒙特利尔认知评估 (MoCA) 评估认知功能;PSCI被定义为MoCA分数<23.

主要成果:

血血栓模块素显示出与PSCI的反向关联.
较高的血栓模块素四分位数与显著降低PSCI风险相关 (OR:0.50,P_趋势=0.026).
每次SD增加的日志转化血栓模块素与PSCI风险降低23% (OR:0.77,P=0.029) 和PSCI风险重新分类的改善相关.

结论:

血血红蛋白水平升高与缺血性中风后患PSCI的风险较低有关.
血血栓模块素可以作为一种有价值的预测生物标志物和PSCI的潜在治疗标.

关键词:

生物标志物生物标志物认知障碍认知障碍是一种认知障碍.缺血性中风是因为缺血性中风.预测预后预测预测血栓模块素 (Thrombomodulin) 是一种血栓的组成部分.

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