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草多糖的自组装纳米输送系统:对黄素生物可用性和分子机制的影响

Qiongdan Hu¹, Xinxing Tang¹, Rui Long¹

¹State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China.

International journal of biological macromolecules

|December 4, 2024

概括

公多糖化物FS60通过形成聚合物来提高黄素的生物可用性,从而改善吸收,并在大鼠中显著增加黄素葡萄糖化物水平. 这种自然的输送系统优化了黄素.

科学领域:

药理学和药物输送药理学和药物输送
自然产品化学自然产品化学
胃肠道生理学胃肠道生理学

背景情况:

黄素 (Cur) 具有较差的水溶性和较低的生物利用性.
公多糖化物FS60显示了改善黄素分散的潜力.
在体内评估FS60-curcuminoid的输送对于了解其有效性至关重要.

研究的目的:

为了优化FS60-curcuminoid聚合物 (FC) 的配方.
评估FC对大鼠库尔库明药理学上的影响.
阐明 FS60 介导的黄素生物可用性增强背后的机制.

主要方法:

优化FS60-curcuminoid聚合物的配方参数.
在老鼠中进行的药理动力学研究,以评估黄素及其代谢物.
对黄糖化物 (Cur-O-Glu) 水平,Cmax和AUC0-12h的分析.
调查FS60对UGT表达,肠细胞输送体和肠道微生物群的影响.

主要成果:

优化FC表现出高封装效率 (88.22%) 和231.48nm的液态动力直径.
FC的使用显著增加了Cur-O-Glu水平,Cmax是单独的黄素的51倍,AUC0-12h是单独的黄素的19倍.
FS60干预增强了Cur-O-Glu的吸收速度,并促进了黄素的摄入.
FS60调节肠道微生物群,以促进黄素的葡萄糖化.

结论:

FS60-curcuminoid纳米输送系统显著提高了黄素在体内生物可用性.
通过多种机制,FS60促进了胃肠道黄素的葡萄糖化和Cur-O-Glu的吸收.
这种方法为提高黄素的治疗潜力提供了一个有希望的策略.

关键词:

生物可用性生物可用性库尔库明是一种黄素.库尔库明葡萄糖化物松树的松树.这是一种多糖化合物.

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