环境和饮食因素与妊娠中期尿路OH-PAHs相关,在一项大型多地点研究中
Anne M Riederer1, Allison R Sherris1, Adam A Szpiro2
1Department of Environmental & Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Environmental research
|December 4, 2024
概括
环境烟草烟雾 (ETS) 在孕妇中显著增加了多环芳 (PAH) 暴露. 环境空气污染和饮食的影响最小,强调需要减少怀孕期间的ETS暴露.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖健康 生殖健康
背景情况:
- 多环芳 (PAH) 暴露与不良健康结果有关.
- 怀孕期间PAH暴露的来源尚不清楚.
- 识别暴露源对于孕产妇和胎儿健康至关重要.
研究的目的:
- 调查怀孕期间尿液中PAH代谢物 (OH-PAHs) 与暴露于环境烟草烟雾 (ETS) 之间的关联.
- 研究OH-PAHs与短期环境空气污染 (PM2.5) 之间的关系.
- 评估OH-PAHs与饮食中摄入富含PAH的食物之间的联系.
主要方法:
- 尿液OH-PAHs和素 (烟草烟雾暴露的标志物) 在美国三个队列的1603名孕妇非吸烟者中进行测量.
- 通过使用修改的丁素四分位数对ETS暴露进行了分类.
- 环境PM2.5暴露被评估使用EPA的降级模型,饮食摄入量被评估使用食物频率问卷.
主要成果:
- 较高的环境烟草烟雾 (ETS) 暴露,以素水平为指标,显着与尿液OH-PAHs增加有关,包括1-氨,2-氨,3-氨和1-氨.
- 同一天的环境PM2.5水平和OH-PAHs之间没有发现显著的关联.
- 自我报告的富含PAH食物的饮食摄入量与OH-PAH水平没有显著的关联.
结论:
- 环境烟草烟雾 (ETS) 是美国孕妇接触多环芳 (PAH) 的主要来源.
- 环境PM2.5和典型的饮食摄入量似乎是怀孕期间PAH暴露的较小贡献者.
- 调查结果强调,迫切需要制定政策和干预措施,以减少孕妇中ETS暴露的严重性.
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