长期体重变化,发生心血管疾病和糖尿病成年人的全因死亡率
Xue Bai1, Lei Zhang2, Xiaoxiao Ji3
1Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China.
Diabetes research and clinical practice
|December 4, 2024
概括
从年轻到中年人的体重变化显著影响美国糖尿病成年人的心血管疾病 (CVD) 和死亡风险. 保持非肥胖状态对于更好的健康结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 从年轻到中年人的体重变化轨迹是慢性疾病发展的关键因素.
- 了解糖尿病患者群体中的这些动态对于有针对性的干预措施至关重要.
- 以前的研究还没有完全阐明与糖尿病成年人的特定体重变化模式相关的长期风险.
研究的目的:
- 调查从年轻到中年人的体重变化与发生心血管疾病 (CVD) 和全因死亡率之间的联系.
- 分析这些关联,特别是在美国糖尿病成年人群中.
- 量化维持非肥胖状态对心脏病发病率的潜在影响.
主要方法:
- 利用了美国国家健康和营养检查调查 (NHANES) 1988-2018年的数据.
- 包括40-79岁的非孕妇糖尿病成年人,在入学前25岁和10年内自报体重数据.
- 随访参与者平均为29.4年,记录心血管疾病事件和全因死亡率.
主要成果:
- 与稳定的非肥胖相比,减肥与不良结果的关联最强,其次是稳定的肥胖和体重增加.
- 在年轻和中年人群中,稳定的肥胖症显著增加了全因死亡风险.
- 据估计,如果总人口从年轻到中年保持不肥胖,可以避免12%的心血管疾病病例.
结论:
- 体重变化模式显著影响美国糖尿病成年人的心血管疾病发病率和全因死亡率.
- 在整个成年期保持稳定的非肥胖状态与降低风险有关.
- 促进糖尿病患者体重管理的干预措施对于预防心血管事件和过早死亡至关重要.
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