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在看似健康的成年人中,基于全年龄谱方程来确定估计的球透率的参考间隔:单中心研究
Qian Liu1,2,3,4, Huan Hang5, Tongdao Xu6
1Department of Laboratory Medicine, Lianyungang Clinical College, Jiangsu University & The Second People's Hospital of Lianyungang, Lianyungang, PR China.
Annals of clinical biochemistry
|December 4, 2024
概括
本研究建立了性别和年龄特定的参考间隔,用于在健康的中国人群中使用全年龄谱方程 (FAS) 估计的淋巴细胞过率 (eGFR). 这些发现对于准确的功能评估和疾病诊断至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 生物统计学 生物统计学
背景情况:
- 精确评估功能是必不可少的,需要精确了解估计的膜过率 (eGFR) 的性别和年龄相关趋势.
- 现有的eGFR评估方法在不同的人口群体中可能缺乏特异性.
- 全年龄谱 (FAS) 方程为综合性功能分析提供了一个潜在的工具.
研究的目的:
- 用全年龄谱 (FAS) 方程分析估计的膜过率 (eGFR) 分布.
- 在健康的中国人群中为eGFR建立性别和年龄特定的参考间隔.
- 为改善功能评估和病管理提供框架.
主要方法:
- 对24 024名健康个体的大量队列的分析.
- 在分配评估中应用CLSI C28-A3指南.
- 使用双面非参数方法 (P2.5-P97.5) 来确定eGFR参考间隔.
主要成果:
- 在健康成年人中,估计的淋巴膜过率 (eGFR) 水平分布不正常.
- 观察到基于性别的显著差异,女性表现出高于男性的eGFR.
- 随着年龄的增长,eGFR下降,不同年龄组和性别之间存在显著差异.
结论:
- 在一个大型的,单个中心的中国人口中,使用FAS方程为eGFR建立了性别和年龄特定的参考间隔.
- 开发的参考间隔为评估健康个体功能提供了一个潜在的框架.
- 这项研究支持改善脏相关疾病的诊断和治疗策略.
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