睡眠呼吸障碍,肥胖和代谢并发症中的性别差异;那加哈马研究
Takeshi Matsumoto1, Kimihiko Murase2, Yasuharu Tabara3
1Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, 54 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan; Department of Respiratory Medicine, Saiseikai-Noe Hospital, 1-3-25 Furuichi, Jyoto-ku, Osaka, 536-0001, Japan.
Respiratory investigation
|December 4, 2024
概括
性差异影响睡眠呼吸障碍 (SDB) 患病率及其与肥胖和代谢问题的联系. 肥胖的绝经前妇女面临更高的SDB风险,特别是糖尿病或代谢综合征.
科学领域:
- 睡眠医学 睡眠医学
- 肥胖问题研究研究
- 代谢健康 代谢健康
背景情况:
- 睡眠呼吸障碍 (SDB) 患病率的性别差异已知,但它们与肥胖和并发症的相互作用仍未得到充分研究.
- 研究这些基于性别的变异对于理解肥胖人口中的SDB至关重要.
研究的目的:
- 探索肥胖个体中SDB患病率的性别差异.
- 为了检查SDB,肥胖和代谢并发症在不同性别和更年期群体之间的关系.
主要方法:
- 评估了7713名社区参与者,使用夜间氧度测量至少两晚.
- 通过手腕动图学衍生的3%氧气脱度指数 (Acti-ODI3%) 评估SDB,将中度至严重的SDB定义为Acti-ODI3% ≥15/h.
- 肥胖被定义为体重指数≥25 kg/m2.
主要成果:
- 在40岁以下的肥胖女性中,中度至重度的SDB患病率为21.6%,而在非肥胖女性中为0%.
- 患有肥胖和糖尿病/代谢综合征的绝经前妇女,中度至重度SDB的几率明显更高 (aOR 86.4/40.4).
- 在绝经前妇女和男性/绝经后妇女之间观察到关于SDB,肥胖和代谢并发症的显著相互作用.
结论:
- 在SDB患病率及其与肥胖和代谢问题的关联方面存在明显的性别差异.
- 绝经前妇女特别容易受到肥胖与SDB相关的后果的影响.
- 肥胖,糖尿病或代谢综合征的组合在绝经前妇女中增加了SDB风险.
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