相关实验视频
Updated: Jun 5, 2025

05:38
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
32
94岁患者双前臂出现异常,对称的皮疹 临床病理学挑战和诊断陷
Anna-Maria Forster1, Beda Muehleisen1
1Department of Dermatology, University Hospital Basel, Basel, Switzerland.
Journal of cutaneous pathology
|December 5, 2024
概括
一种罕见的侵袭性Trichophyton rubrum感染模仿了在接受PD-1抑制剂治疗的94岁患者的骨髓菌. 这一案例凸显了诊断方面的挑战,以及对侵入性真菌感染进行确认测试的必要性.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- (Trichophyton rubrum) 通常会在免疫能力强的个体中引起表面皮肤感染.
- 侵袭性皮肤菌感染不常见,主要影响免疫抑制患者,如器官移植接受者.
研究的目的:
- 报告一个不同寻常的Trichophyton rubrum侵袭性感染病例,感染了两只前臂.
- 为了突出T. rubrum模仿皮肤芽细胞菌所带来的诊断挑战.
- 强调在非典型的真菌感染中进行确认性检测的重要性.
主要方法:
- 皮肤活检样本的组织病理学检查.
- 元素的形态和染色特性.
- 考虑患者的病史,包括免疫抑制和抗PD-1治疗.
主要成果:
- 一名94岁的男性出现了对称的双边前臂病变.
- 组织病理学揭示了侵袭性T. rubrum与异型形态类似于Blastomyces dermatitidis的异型形态.
- 该患者正在接受全身抗PD-1检查点抑制剂治疗.
结论:
- 侵袭性T. rubrum可以呈现异常形态,模仿其他真菌感染,如胚芽菌.
- 同时使用抗PD-1治疗可能是侵袭性真菌感染发展的一个因素.
- 准确的诊断需要形态学,染色和确定方法 (如培养或PCR测试) 的结合.
相关概念视频
Endocarditis II: Clinical features and Diagnostic Tests
1
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
1
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
2
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
2
Rheumatic Heart Disease I: Introduction
2
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
2
Myocarditis II: Clinical features and Diagnostic Tests
1
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
1
Assessment of the Cardiovascular System II: Inspection
175
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
175
Assessment of the Cardiovascular System III: Palpation
193
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
193

