克罗辛补充剂对炎症和氧化应激:系统性审查和元分析
Hossein Bahari1, Mostafa Shahraki Jazinaki2, Ladan Aghakhani3
1Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytotherapy research : PTR
|December 5, 2024
概括
克罗辛补充剂显著降低了CRP,TNF-α和IL-6等炎症标志物,同时提高了总抗氧化能力 (TAC). 更高的剂量 (≥30mg/天) 和更长的持续时间 (≥12周) 显示出更大的抗炎作用.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 沙夫兰的活性化合物,crocin,是一种具有已知的抗炎和抗氧化特性的胡卜素.
- 现有的关于crocin对炎症和氧化应激的影响的研究是不确定的.
- 克罗辛是从Crocus sativus L.花的印中获得的.
研究的目的:
- 进行一项元分析,评估素补充剂的益处.
- 评估crocin对炎症和氧化应激标志物的特定影响.
- 综合关于补充crocin的随机临床试验 (RCT) 的发现.
主要方法:
- 在PubMed/Medline,Scopus和Web of Science进行了全面的文献搜索,截至2024年2月.
- 包括随机临床试验 (RCT) 涉及成年参与者补充crocin.
- 分析数据使用随机效应模型,异质性测试 (I2统计),并计算了加权平均差异 (WMD) 与95%置信区间 (CI).
主要成果:
- 克罗辛补充剂显著降低了C反应性蛋白 (CRP),瘤亡因子-α (TNF-α) 和互白素-6 (IL-6) 的水平.
- 显著增加了总抗氧化能力 (TAC).
- 红细胞沉积率 (ESR) 或马隆迪化物 (MDA) 水平没有显著变化. 剂量≥30mg/天和持续时间≥12周时,效果更为明显.
结论:
- 补充克罗辛可以有效地减少关键的炎症标志物,并提高总抗氧化能力.
- 观察到较高剂量和较长干预期的最佳治疗效果.
- 需要进一步的研究来确定关于crocin疗效的最终结论.
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