肺炎球菌血型和抗菌素耐药性模式的疫苗前后趋势
Sreeram Chandra Murthy Peela1, Sujatha Sistla1, Geetha Nagaraj2
1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.
The Indian journal of medical research
|December 5, 2024
概括
印度的肺炎球菌疫苗接种减少了疫苗血型,但增加了耐药菌株,如19F和19A. 非疫苗血清型在引入后略有增加.
科学领域:
- 微生物学 微生物学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 肺炎球菌疫苗于2021年在印度的通用免疫计划 (UIP) 中推出.
- 有限的数据存在于印度疫苗引入后的血清型转移.
- 这项研究评估了疫苗推出前后的血清型和抗菌素耐药性的变化.
研究的目的:
- 估计肺炎球菌血清型和抗菌素耐药性模式的变化.
- 来自第三级护理中心的疫苗引入前后数据进行比较.
- 评估肺炎球菌疫苗接种对循环菌株的影响.
主要方法:
- 从疫苗接种前 (2015年1月至2021年7月) 和疫苗接种后 (2021年8月至2023年3月) 期的临床分离物分析.
- 通过光盘扩散或VITEK2进行抗菌敏感性测试.
- 使用Quellung测试或多重PCR进行血清分型;使用Chi-square,Fisher精确和z测试进行统计分析.
主要成果:
- 在疫苗后的时代,对大多数抗生素的耐药性增加.
- 血清型19F和15B/C的比例增加;23F和14的比例下降.
- 大多数持久的19F和19A分离物是多药耐药的.
结论:
- 肺炎球菌疫苗接种减少了许多疫苗血清型的负担.
- 观察到非疫苗血清型略有增加.
- 在疫苗接种后的时代,持续的疫苗血清型 (19F,19A) 呈现出显著的耐药性.
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