长期胆囊切除术患者的代谢功能障碍相关脂肪肝疾病:一个跨部分研究
Semih Sezer1, Selim Demirci1, Murat Kara2
1Departments of Gastroenterology Medicine, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Türkiye.
概括
胆囊切除术显著增加了患有代谢功能障碍相关脂肪肝疾病 (MAFLD) 的风险. 经过胆囊切除术的患者患MAFLD的可能性是4.5倍,特别是在10年后.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 外科手术的结果
背景情况:
- 胆囊切除术是一种常见的手术,通常被认为是安全的.
- 新出现的证据将胆囊切除术与增加的代谢并发症联系起来.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题.
研究的目的:
- 调查胆囊切除术与MAFLD的患病率之间的联系.
- 确定胆囊切除术是否是MAFLD的独立风险因素.
主要方法:
- 横截面研究设计. 截面研究设计.
- 由肝肥胖症加上糖尿病,超重 (BMI ≥25 kg/m2) 或代谢失调定义的MAFLD.
- 在胆囊切除术 (N=83) 与非胆囊切除术 (N=80) 的参与者中,MAFLD患病率的比较.
主要成果:
- 在胆囊切除术患者 (77.1%) 中,MAFLD的患病率明显高于对照组 (37.5%) (P < .001).
- 胆囊切除术 (OR=4.540) 和BMI (OR=1.155) 独立地与MAFLD相关.
- 在胆囊切除术10年后,MAFLD风险显著增加.
结论:
- 胆囊切除术与MAFLD的可能性增加了4.5倍.
- 胆囊切除术后的时间随着MAFLD风险的升级,特别是在10年以后.
- 对于经过胆囊切除术的患者,建议对MAFLD进行常规监测.
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