性状病变:在中国寻找真正的流行率和危险因素
Bing-Yue Yao1, Li Zhang2, Chuan-Xia Wu3
1Department of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
概括
状状病变 (SSL) 是结直肠癌 (CRC) 的前体. 在中国,SSL检测率为5.4%,肥胖是高级SSL的重要独立风险因素.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内镜检查是指内镜检查.
背景情况:
- 状状病变 (SSL) 越来越多地被认为是结直肠癌 (CRC) 的前体.
- 目前对SSL患病率和风险因素的理解,特别是在亚洲人群中,仍然有限.
- 准确的检测率和影响因素对于有效的CRC预防策略至关重要.
研究的目的:
- 为了确定SSL在中国的真正流行率.
- 确定与SSL开发相关的临床和内镜风险因素.
- 分析SSL在中国大群体中的检测率.
主要方法:
- 来自上海东医院的结肠镜数据的回顾分析 (2019年3月 - 2022年2月).
- 包括患者的人口统计,病变特征和病理发现.
- 专注于SSL检测率和相关风险因素.
主要成果:
- 总共进行了72,287次结肠镜检查,发现了3,905例SSL病例,总体检测率为5.40%.
- 与女性 (4.6%) 相比,男性的SSL检测率更高 (6.1%).
- 肥胖 (BMI ≥24),CRC家族病史和高血压与SSL相关,肥胖被确定为SSL与发育不良/腺癌 (SSL-D/AD) 的独立风险因素.
结论:
- 在这个中国队列中,SSL检测率为5.4%,随着年龄的增长而增加,在男性中更高.
- 内镜医生应了解SSL-D/AD的危险因素,如肥胖,家族史CRC,高血压等.
- 需要进一步的研究来完善检测策略,并了解SSL的病原性.
相关概念视频
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
01:08Prevalence and Incidence
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...