跳过现象在患有持续性黄金葡萄球菌菌血症的患者中的临床影响
Sukbin Jang1, Minji Jeon2, Si-Ho Kim3
1Division of Infectious Diseases, Department of Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea.
概括
在 Staphylococcus aureus bacteremia (SAB) 中的跳过现象 (SP) 可以隐藏长期感染. SP可能会低估细菌病持续时间超过一周,特别是MRSA,需要连续负血培养.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 跳过现象 (SP),间歇性阴性血液培养,在黄金杆菌菌菌病 (SAB) 中很常见.
- 持续性SAB中SP的临床意义尚不清楚.
研究的目的:
- 调查SP在患有持续SAB的患者中的临床影响.
- 为了确定预测因素和SP对治疗持续时间和结果的影响.
主要方法:
- 在四所大学医院进行的回顾性队列研究.
- 对221名持久性SAB患者的分析,确定了SP患者.
- 与SP患者和无SP患者之间的临床特征和结果的比较.
主要成果:
- SP发生在11.3%的持久SAB.患者中.
- 甲素耐药黄金菌 (MRSA) 感染在SP患者中更为常见.
- 脊髓炎患者的细菌病持续时间较长,抗生素治疗延迟,住院死亡率较低 (12.0%与30.6%相比).
- 细菌病持续时间和MRSA是SP的独立预测因素.
结论:
- SP可能导致细菌病持续时间低估超过一周.
- 连续阴性血液培养可能对于排除长期MRSA细菌血症中SP至关重要.
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