比菲多细菌动物 Probio-M8 通过减轻微生物代谢产物所施加的肌酸限制,改善了肉症的身体表现
Zeng Zhang1, Yajing Fang1, Yangli He2
1School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou, Hainan, China.
NPJ biofilms and microbiomes
|December 5, 2024
概括
像Probio-M8这样的益生菌有望对抗肉,通过积极改变肠道细菌及其代谢物来改善老年人的肌肉功能和身体表现.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 代谢学 代谢学 代谢学
背景情况:
- 肉症对健康构成重大挑战,特别是在全球人口老龄化方面.
- 肠-肌肉轴对萨尔科佩尼亚来说是一个潜在的治疗点,益生菌正在研究它们的益处.
- 益生菌在治疗肉症的具体机制和有效性需要进一步阐明.
研究的目的:
- 为了研究Bifidobacterium animalis亚种的影响. 乳糖 益生菌-M8 (益生菌-M8) 关于老年小鼠和人类患者的肉症.
- 探索Probio-M8的潜力通过调节肠道微生物代谢物通过多omics方法来改善肉症.
主要方法:
- 采用了多omics方法,分析了43名受试者的肠道微生物组,便代谢组和血清代谢组 (老年小鼠和肉病患者).
- 该研究评估了Probio-M8干预后微生物组成,代谢物概况和身体表现的变化.
主要成果:
- 在老年小鼠中,Probio-M8的使用显著改善了肌肉功能,在肉症患者中提高了体力表现.
- 益生菌干预导致了致病性肠道细菌的减少和有益代谢物的增加,包括英多尔-3-乳酸,乙酸和肌酸.
- 调解作用分析表明,Probio-M8降低了肠道n-dodecanoyl-L-homoserine乳,并增加了肌酸循环,增强了其物理特性.
结论:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖 益生菌-M8在改善肌肉功能和与肉症相关的身体表现方面表现出有效性.
- 通过Probio-M8调节肠道微生物代谢物,如肌酸,在对宿主物理性质的有益影响中起着关键作用.
- 这些发现凸显了益生菌作为治疗萨尔科佩尼亚的潜在治疗策略,针对肠道微生物群的新陈代谢.
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