系统性免疫炎症指数的高水平提高了重症监护病房患者的妄想风险
Feifei Xu1, Shurong Zhang1, Yanyuan Zhang2
1Department of Critical Care Medicine, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, People's Republic of China.
Scientific reports
|December 5, 2024
概括
系统性免疫炎症指数 (SII) 与重症监护室 (ICU) 患者 Delirium 的风险更高有关. 增加的SII也与这些患者的死亡率增加有关.
科学领域:
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 痴呆症是重症监护室 (ICU) 患者常见的并发症.
- 关于系统性免疫炎症指数 (SII) 对妄的影响的证据有限.
- 调查新生物标志物用于妄想风险分层是至关重要的.
研究的目的:
- 检查系统性免疫炎症指数 (SII) 与 Delirium 的发生之间的关联.
- 评估SII与ICU患者的短期 (30天和90天) 全因死亡率之间的关系.
主要方法:
- 使用了来自密集护理-IV (MIMIC-IV) 数据库的医疗信息中心的数据.
- 使用后勤回归,子组分析,限制立方线 (RCS) 和倾向得分匹配 (PSM).
- 使用接收器操作员特征曲线 (ROC) 确定最佳SII切线值,并使用生存分析评估死亡率.
主要成果:
- 总共分析了7,518名患者,其中1,685人患有妄想症.
- 最高四分位数的SII与 Delirium 的风险增加显著相关 (OR 3.12).
- 较高的SII水平与30天和90天死亡率的风险增加约50%相关.
结论:
- 系统性免疫炎症指数 (SII) 的升高与ICU患者的 Delirium 发病率有关.
- 较高的SII水平与ICU环境中所有原因死亡的风险更高有关.
- SII可以作为一种潜在的预测性生物标志物,用于痴呆症和重症监护中的死亡率.
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