在超临界二氧化碳中测量和建模硫沙拉的可溶性,以选择生产纳米颗粒的方法
Yahia Alghazwani1, Mohammed Ghazwani2, Sirajunisa Talath3
1Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Scientific reports
|December 5, 2024
概括
这项研究测量了在各种温度和压力下在超临界二氧化碳 (ScCO2) 中的硫沙拉溶解度. 结果表明,ScCO2是使用气体抗溶剂方法生产纳米粒子的一个有希望的介质.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 苏尔法萨拉是一种在常规溶剂中溶解度有限的药物.
- 超临界流体,特别是二氧化碳,为溶解性操纵提供可调节的特性.
- 了解溶解度对于开发先进的药物输送系统和制造工艺至关重要.
研究的目的:
- 通过实验来确定硫沙拉在超临界二氧化碳 (ScCO2) 中的可溶性.
- 用各种热力学模型建模和关联可溶性数据.
- 评估ScCO2在硫素纳米粒子生产中的潜力.
主要方法:
- 在 313 K 到 343 K 的温度和 12 到 30 MPa 的压力下,实验性地确定硫沙拉在 ScCO2 中的溶解度.
- 使用半实证相关性,-罗宾逊方程,PC-SAFT方程和常规溶液模型,对溶度数据的相关性.
- 在预测实验溶解度值时分析模型性能.
主要成果:
- 在所研究的条件下,sulfasalazine在ScCO2中的分子溶解度从4.08 × 10−5到16.35 × 10−5不等.
- 溶解度通常随着压力增加而增加,随着温度下降.
- 半经验,状态方程 (Peng-Robinson,PC-SAFT) 和常规解决方案模型准确地将实验数据相关联起来.
结论:
- 超临界的二氧化碳具有明显的溶解硫素的潜力.
- 热力学模型有效地预测了硫沙拉在ScCO2中的溶解度,有助于过程设计.
- 使用ScCO2的气体抗溶剂方法是生产硫素纳米颗粒的可行策略.
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