2型糖尿病和过去的COVID-19在活跃结核病上的相互作用
Liz E Calles-Cabanillas1, Genesis P Aguillón-Durán1, Doris Ayala1
1School of Public Health, University of Texas Health Science Center at Houston, One West University Blvd, SPH Bldg, Brownsville, TX, 78520, USA.
过去的COVID-19和糖尿病 (DM) 协同增加结核病 (TB) 风险. 对于有COVID-19和DM病史的个人,建议对潜伏结核病进行查.
科学领域:
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 全球结核病 (TB) 控制工作在COVID-19后遭遇挫折,部分原因是医疗保健中断.
- COVID-19对结核病发病率的直接生物学影响尚不清楚.
- 研究过去的COVID-19感染和结核病风险之间的相互作用至关重要.
研究的目的:
- 为了确定最近的COVID-19感染和新的结核病发作之间的关联.
- 评估2型糖尿病 (DM) 伴随性疾病在该协会中的改变作用.
主要方法:
- 一项涉及112名新的活跃结核病患者和373名非结核病对照的横截面研究.
- 2020年6月至2021年11月期间在美墨边境沿线社区收集的数据.
- 通过自我报告或血清学确定过去的COVID-19状态;统计分析包括双变量和多变量模型.
主要成果:
- 过去的COVID-19与新结核病的几率增加有关,特别重要的是患有DM的患者 (调整后的几率比率[aOR] 2.3).
- 患有DM的人在没有先前的COVID-19的情况下患结核病的几率高出2.7倍.
- 这种风险在DM和COVID-19病史患者中增加了7.9倍的结核病几率.
结论:
- 2型糖尿病和过去的COVID-19协同相互作用,显著放大结核病风险.
- 建议对于有COVID-19和DM病史的个人进行潜在结核病查和预防性治疗.
- 强调需要使用更大的样本大小进行纵向研究来验证这些发现.
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