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早期引入IL-10通过抑制CD4+Th1细胞反应来削弱BCG再接种疫苗的保护

Qing Lei1, Hui Fu1, Zongjie Yao1

  • 1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Huazhong University of Science and Technology, Wuhan, China.

Journal of translational medicine
|December 5, 2024
PubMed
概括

在Bacillus Calmette-Guérin (BCG) 疫苗接种后阻断IL-10信号,可以提高T细胞的反应,并改善对小鼠结核病 (TB) 感染的保护. 这一发现对于开发更好的结核病疫苗至关重要.

关键词:
大人的结核病.在BCG的首次提升策略中,BCG的主要提升策略是:重复接种BCG疫苗的方法它可以抑制IL-10的抑制.记忆 CD4+ T 细胞原发性 Mycobacterium 结核病感染

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