牙周病与全身性疾病之间的关联:对当前证据的横截面分析
Di Huang1, Yun-Yun Wang1, Bing-Hui Li2
1Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
Military Medical Research
|December 5, 2024
概括
牙周病与各种系统性疾病的风险增加有关,包括癌症,心血管,代谢和神经系统疾病. 然而,评估这些联系的现有审查的质量往往非常低,需要改进研究标准.
科学领域:
- 口腔健康和全身疾病
- 证据综合和质量评估
背景情况:
- 有许多关于牙周病和全身疾病的系统性审查和元分析.
- 这些现有审查的质量需要进行批判性评估.
- 本研究提供了横截面分析证据,将牙周病与全身性疾病联系起来.
研究的目的:
- 系统地分析和评估有关牙周病和全身性疾病之间的关联现有系统审查和元分析的质量.
- 确定与牙周病相关的全身性疾病的范围.
- 评估证据基础的方法严谨性.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆系统搜索相关的评论.
- 纳入标准:研究检查牙周病作为暴露和系统性疾病作为结果.
- 使用修改后的A测量工具进行质量评估,以评估系统审查2 (AMSTAR 2) 和使用R软件进行统计分析.
主要成果:
- 包括57个系统性审查和元分析,涵盖75种疾病和81种结果.
- 在67个结果中发现了显著的关联;癌症是最常见的主题.
- 头癌的最高风险估计 (OR=3.17);胎囊过早破裂的最低风险估计 (RR=1.10).
- 方法质量主要为"非常低" (71.93%) 或"低" (17.54%).
结论:
- 牙周病与许多癌症,心血管,代谢和神经结果的风险显著增加有关.
- 现有的关于这个主题的系统审查和元分析的现有机构的方法质量不足.
- 提高未来系统审查的质量对于产生可靠的证据至关重要.
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