人类癌症中的TRPM通道:调节机制和治疗前景
Qinfeng Liu1, Mengyu Hu1, Shi Li1
1National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430074, China.
Biomarker research
|December 5, 2024
概括
瞬态受体潜在拉斯 (TRPM) 通道越来越多地与癌症有关,影响瘤生长和转移. 准TRPM道为癌症治疗和免疫治疗提供了潜在的新策略.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 离子通道生理学 离子通道生理学
背景情况:
- 暂时受体潜在的 Melastatin (TRPM) 通道与疾病有关,包括癌症.
- 在各种恶性瘤中,TRPM通道表现出支持和抗瘤的功能.
- 它们参与瘤细胞的增殖,生存,入侵和转移,作为潜在的生物标志物.
研究的目的:
- 描述TRPM通道家族成员的结构和生理功能.
- 概述TRPM通道在胰腺,前列腺,结直肠,乳腺,脑癌和黑色素瘤等常见癌症中的作用.
- 从瘤微环境和细胞内信号传递中研究TRPM通道参与瘤发生的机制.
主要方法:
- 文献综述和对TRPM道在癌症中的现有研究进行分析.
- 检查TRPM通道参与瘤细胞功能,包括增殖,存活,入侵和转移.
- 分析TRPM道在信号通路 (Wnt/β-catenin,MAPK,PI3K/AKT,p53,自) 和瘤微环境中的作用.
主要成果:
- TRPM通道参与瘤细胞的增殖,生存,入侵和转移.
- 它们调解细胞外矩阵重塑,帮助恶性转变.
- TRPM通道调节离子流入,并参与关键的癌症信号通路.
结论:
- 在癌症的发展和进展中,TRPM通道至关重要.
- 准TRPM道在癌症治疗中提供了治疗机会和挑战.
- 将TRPM道向药物与癌症免疫疗法结合起来是一个有希望的未来方向.
相关概念视频
Mechanically-gated Ion Channels
6.2K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.2K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Receptor Downregulation in MVBs
2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.0K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Transducer Mechanism: Enzyme-Linked Receptors
2.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.4K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K


