静态和立体高血压和心血管疾病的风险
Sean W Dooley1, Fredrick Larbi Kwapong1, Hannah Col1
1Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.).
Hypertension (Dallas, Tex. : 1979)
|December 5, 2024
概括
正静性高血压的定义各不相同. 站立时系统性血压显著上升并没有预测心血管疾病 (CVD),但站立时高的系统性血压确实如此. 这表明这些条件存在明显的风险.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 公共卫生 公共卫生
背景情况:
- 正静性高血压是不良健康事件的新兴风险因素.
- 目前的定义将站立时血压升高与站立时高血压相结合.
- 这两个组成部分的独特心血管疾病 (CVD) 风险尚未得到充分理解.
研究的目的:
- 调查静脉静脉压升高 (静脉静脉压升高[SBP]≥20 mm Hg) 和站立静脉压升高 (站立静脉压升高≥140 mm Hg) 是否与心血管疾病结局有相似的关联.
- 检查正静性高血压的新共识定义.
主要方法:
- 利用了社区动脉样硬化风险研究 (ARIC) 的数据,测量卧卧和站立的血压.
- 确定的缩静止增加和升高的站立SBP.
- 采用考克斯回归来分析30年来发生冠心病,心力衰竭,中风,致命冠心病和全因死亡率的关联.
主要成果:
- 系统性静止体增加与不良结果没有显著关联.
- 站立SBP升高 (≥140 mm Hg) 与所有研究的心血管疾病终点和全因死亡率有显著关联.
- 持久的SBP≥140mmHg显示,心血管疾病的风险明显高于静脉静脉增加.
结论:
- 站立时静脉压升高 (≥140 mm Hg) 与心血管疾病的结果和死亡率密切相关.
- 仅仅是静脉静态增加似乎并不是心血管疾病的重要危险因素.
- 这些发现引发了人们的担忧,因为由于风险概况不同,在对静止高血压的共识定义中,结合心筋静止血压的增加和恒定的SBP≥140 mm Hg.
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