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Updated: Jun 5, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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蛋白质序列和结构的双语语言模型

Michael Heinzinger1, Konstantin Weissenow1, Joaquin Gomez Sanchez1

  • 1School of Computation, Information, and Technology (CIT), Department of Informatics, Bioinformatics & Computational Biology, TUM (Technical University of Munich), 85748 Garching/Munich, Germany.

NAR genomics and bioinformatics
|December 5, 2024
PubMed
概括

我们开发了 ProstT5,一种新型的蛋白质语言模型 (pLM),集成了 3D 结构和 1D 序列数据. 这种方法增强了与结构相关的预测,并加速了蛋白质结构数据库的分析.

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Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Protein and Protein Structure

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Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Termination of Translation

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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