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Updated: Jun 5, 2025

Measurement of Lifespan in Drosophila melanogaster
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Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

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在TGF-β信号通路组件中的突变调节了Drosophila melanogaster的寿命

Virginia Fife1, Margarita Kyza-Karavioti1, Ioannis Eleftherianos1

  • 1Biological Sciences, George Washington University, Washington, Washington, D.C., United States.

microPublication biology
|December 5, 2024
PubMed
概括

转化生长因子β (TGF-β) 信号通路的突变,包括骨形态蛋白 (BMP) 和活性蛋白,显著改变成年果 (Drosophila melanogaster) 的寿命. 这些发现强调了TGF-β信号作为长寿的关键调节者.

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Methods to Test Endocrine Disruption in Drosophila melanogaster

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The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

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TGF - β Signaling Pathway01:16

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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