修改的快速变更方法用于在重症患者中交换上腺素注射器:一个准随机的,非劣势试验
Reiko Iwamoto1, Seiya Kanou2,3, Eiji Nakatani4
1Department of Nursing, Fujieda Municipal General Hospital, Fujieda, JPN.
Cureus
|December 5, 2024
概括
修改快速更换 (mQC) 方法用于在接受北上腺素输注的重症患者的注射器交换,与双 (DP) 方法不逊色. 这种简单的mQC技术提供了可比的安全性,并可能成为标准.
科学领域:
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
- 医疗器械 医疗器械
背景情况:
- 危急病患者往往需要持续的静脉输入上腺素输注以获得血液动力学支持.
- 输注的注射器交换方法,如双 (DP),可能是复杂的.
- 修改快速更换 (mQC) 方法是注射器交换的潜在替代方案.
研究的目的:
- 为了验证修改的快速更换 (mQC) 方法是否不劣于常规的双 (DP) 方法用于注射器交换.
- 评估mQC方法的安全性和有效性,在接受诺亚上腺的重症患者中.
- 评估mQC方法作为标准交换技术的潜力.
主要方法:
- 进行了一项非盲目的,准随机的,非劣等性试验.
- 包括接受连续静脉输入上腺素输注的成年患者.
- 根据入院月份,患者被分配到mQC或DP组.
- 主要终点是交换后平均动脉压的差异.
主要成果:
- 平均动脉压的平均差异为mQC的 -8.92 mm Hg和DP的 -10.63 mm Hg.
- 对差异的95%置信区间在10mmHg的非劣势率范围内.
- 证实mQC方法不低于DP方法.
结论:
- 在这个患者群体中,mQC方法与用于注射器交换的DP方法并没有劣势.
- 该mQC方法显示了可比的安全概况和更简单的程序.
- 建议进行进一步的大规模随机对照试验,以验证这些发现.
更多相关视频
相关概念视频
Drug Delivery: Enteral Route
377
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
377
Depolarizing Blockers: Pharmocokinetics
305
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
305
Adrenergic Agonists: Therapeutic Uses
728
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
728


