皮质醇对中风后认知和情绪障碍的影响:范围审查
Tiantian Wang1, Xuan Li1, Yuanyuan Jia1
1Rehabilitation Medical Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Heliyon
|December 5, 2024
概括
卒中后皮质醇水平高可能预测未来的认知能力下降和抑郁症. 这一发现表明皮质醇可以作为中风后情绪和认知健康的早期生物标志物.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 神经学 神经学
背景情况:
- 卒中往往导致认知和情绪障碍.
- 下垂体-垂体-上腺 (HPA) 轴及其主要激素皮质醇与这些中风后的疾病有关.
- 现有的研究探讨了皮质醇水平与中风后认知障碍 (PSCI) 和中风后抑郁症 (PSD) 之间的联系.
研究的目的:
- 进行范围审查,澄清皮质醇对PSCI和PSD的影响.
- 为临床诊断和治疗这些疾病提供理论基础.
主要方法:
- 在PubMed,科学网,科克兰图书馆,CNKI和万芳数据库中搜索到2023年10月的文献.
- 包括对缺血性或出血性中风患者的横截面和队列研究.
- 从血液,唾液或头发样本中分析的皮质醇水平.
主要成果:
- 审查中包括了18项研究.
- 大多数中风患者表现出基底皮质醇水平升高和皮质醇改变的昼夜节律.
- 较高的入院皮质醇水平与以后认知能力下降和抑郁症的可能性增加有关.
结论:
- 入院皮质醇水平显示为预测中风后认知和情绪结果的生物标志物具有前途.
- 这突显了HPA轴调节失调在中风后长期后果中的潜在作用.
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