根据常规临床实践中早期维护阶段反应预测过敏原免疫疗法的疗效
Rundong Qin1, Wanyi Fu1, Renbin Huang1
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, 151, Yanjiangxi Rd, Guangzhou, Guangdong, 510120, China.
The World Allergy Organization journal
|December 5, 2024
概括
在过敏原特异性免疫疗法 (AIT) 维持期间早期降低症状得分预测了长期治疗的成功. 这一发现有助于确定有效的AIT响应者用于家用粉尘虫过敏.
科学领域:
- 过敏学和免疫学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 过敏原特异性免疫疗法 (AIT) 是有效的,但具有可变的结果.
- 对于AIT响应的预测标志物尚未得到充分确立.
- 确定可靠的预测因子对于优化患者治疗至关重要.
研究的目的:
- 在日常实践中确定预测AIT响应者的临床参数.
- 评估AIT在患有家尘引发的喘/鼻炎的患者中的疗效.
- 寻找成功长期AIT的早期指标.
主要方法:
- 对133名接受3年皮下AIT的患者进行了回顾性分析.
- 使用估计的每日症状和药物评分 (edSMS) 评估疾病控制.
- 响应者的定义基于≥30%的edSMS从增加剂量到维护III阶段的减少.
主要成果:
- 在AIT的3年后,疾病状况的整体改善.
- 受访者具有较低的多敏感性,较少的烟草烟雾暴露,以及较轻的预治疗严重性.
- 早期减少edSMS (增加剂量到维持I) 显著预测了3年AIT结果 (p < 0.001).
- ΔedSMSU-M1 > 18.40%的预测响应者具有76.20%的灵敏度和76.70%的特异性.
结论:
- 对AIT的个性化临床反应在预测疗效方面存在挑战.
- 在维持阶段早期治疗的有效性是3年AIT结果的可靠预测指标.
- 这项研究为AIT成功提供了实际的临床指标.
相关概念视频
02:06Allergic Reactions
27.2K
Overview
27.2K
01:23Immunological Memory
530
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
530
01:27Allergic Drug Reactions
812
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
812
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
237
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
237
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K