系统性炎症反应指数升高与轻度缺血性中风的不良结果有关
Jie Li1,2, Ping Zhang1,2, Hong Chen1,2
1Department of Neurology, Deyang People's Hospital, Deyang, China.
Frontiers in neurology
|December 5, 2024
概括
系统性炎症反应指数 (SIRI) 水平升高与轻度缺血性中风 (MIS) 患者90天功能表现不佳有关. SIRI可能有助于识别高风险的MIS患者,以制定个性化治疗策略.
科学领域:
- 神经学 神经学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 轻度缺血性中风 (MIS) 经常导致严重的长期残疾.
- 识别MIS患者功能表现不佳的早期指标对于及时干预至关重要.
研究的目的:
- 研究被诊断为MIS的患者的全身炎症反应指数 (SIRI) 和3个月功能结果之间的关联.
- 确定SIRI是否可以作为MIS后残疾的预测生物标志物.
主要方法:
- 一项前性观察性研究招募了152名MIS患者 (NIHSS得分0-3) 在症状出现后24小时内.
- 系统性炎症反应指数 (SIRI) 从入院时采集的血液样本中进行测量.
- 在90天后,使用修改的兰金尺度 (mRS) 评估了功能性结果,得分为2-6表示结果不佳.
主要成果:
- 15.8%的MIS患者在90天后出现不良结果.
- 结果不佳的患者与结果好 (1.21) (p=0.003) 的患者相比,表现出明显更高的中位数SIRI水平 (1.93),比表现良好的患者要高得多 (p=0.003).
- 在多变量分析中,较高的SIRI (>1.27 × 10 ^ 9 / L) 与90天不良结果的风险增加 (OR: 1.57,p = 0.010) 和显著的风险因子 (OR: 4.80,p = 0.008) 独立相关.
结论:
- 在MIS患者中,SIRI水平升高是常见的,并且与90天后功能表现不佳显著相关.
- 该SIRI显示了作为一个有价值的生物标志物的潜力,用于识别具有较高残疾风险的MIS患者.
- 利用SIRI可以帮助量身定制治疗决策,并在MIS临床试验中对患者进行分层.
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