在患有缺铁性贫血的儿童中,每日补充铁与间歇补充铁:元分析
1Sawsan Mohammed Alblewi Pediatrics Department, Faculty of Medicine, University of Tabuk, Saudi Arabia, PO Box 3378 Tabuk 51941, Saudi Arabia.
Pakistan journal of medical sciences
|December 5, 2024
概括
与间歇剂量相比,每天补充铁可以显著改善铁缺乏性贫血儿童的血红蛋白水平. 建议对耐受性和遵守性进行进一步的研究.
科学领域:
- 儿童营养学 儿童营养学
- 血液学 血液学 血液学
- 基于证据的医学基于证据的医学.
背景情况:
- 缺铁性贫血是全球儿童中普遍存在的营养障碍.
- 最佳的铁补充策略对于有效的治疗和预防至关重要.
- 了解每日和间歇铁剂量的疗效对于临床实践至关重要.
研究的目的:
- 进行一项元分析,比较儿童每日与间歇性铁补充剂的有效性.
- 评估不同铁补充方案对血红蛋白水平的影响.
主要方法:
- 在主要数据库 (Cochrane Library,PubMed,Medline,Google Scholar) 中进行了系统的文献搜索.
- 包括涉及2个月至18岁儿童的随机对照试验 (RCT).
- 分析了2012年1月至2023年11月期间发表的研究,使用与缺铁性贫血和补充计划相关的关键词.
主要成果:
- 在735项初步研究中,10项RCT符合纳入标准.
- 与间歇补充剂相比,每日补充铁显示出血红蛋白水平的统计学上显著改善 (OR 0.41与0.69,P <0.001).
结论:
- 每天补充铁比间歇性治疗方案 (每周或每周两次) 更有效提高贫血儿童的血红蛋白.
- 需要进行更大规模的研究来进一步评估与每日铁疗法相关的耐受性和遵守性.
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