与SARS-CoV-2和登革热病毒的同时感染:一个案例报告强调了诊断挑战
Prasetyo Hariadi1, Dewi Lokida1,2, Adhella Menur Naysilla2
1Tangerang District Hospital, Tangerang, Indonesia.
Frontiers in tropical diseases
|December 5, 2024
概括
与严重急性呼吸系统综合征相关的冠状病毒2 (SARS-CoV-2) 和登革热病毒 (DENV) 的同时感染在流行地区带来了诊断挑战. 早期怀疑和意识到重叠的症状对于准确的诊断和患者管理至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸系统综合征相关的冠状病毒2 (SARS-CoV-2) 已经造成全球大流行,影响登革热病毒 (DENV) 流行地区.
- 与SARS-CoV-2和DENV的同时感染会造成诊断困难,特别是在资源有限的环境中,如印度尼西亚.
- 在COVID-19和登革热之间重叠的临床症状需要仔细的临床评估.
研究的目的:
- 突出在登革热流行地区识别SARS-CoV-2感染的诊断挑战.
- 为了呈现与SARS-CoV-2和登革热同时感染的病例.
- 强调保持对共感染的高怀疑指数的重要性.
主要方法:
- 一个68岁的女性患有II型糖尿病,出现了暗示登革热的症状.
- 诊断测试包括SARS-CoV-2的RT-PCR和登革热的血清测试 (IgM,IgG,HI抗体标位).
- 临床管理涉及SARS-CoV-2的支持性护理和抗病毒治疗.
主要成果:
- 患者最初出现的症状是登革热和COVID-19之间重叠的症状.
- 通过RT-PCR证实了SARS-CoV-2感染.
- 通过IgM和高IgG标位的血清转换建立了回顾性登革热诊断,表明了二次登革热感染.
- 患者的临床状况有所改善,在对SARS-CoV-2的检测结果呈阴性后被出院.
结论:
- 重叠的临床表现和有限的诊断能力使得在登革热流行地区发现COVID-19变得复杂.
- 流行地区的临床医生必须对SARS-CoV-2与DENV和其他热带病原体的共同感染保持警.
- 保持高的怀疑指数对于及时和准确的诊断至关重要.
相关概念视频
00:57Viral Recombination
22.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
22.3K
01:05Single Nucleotide Polymorphisms-SNPs
14.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.6K
01:23Investigation of Disease Outbreaks
74
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
74