开发体积定量评估软件,用于评估呼吸诱导的目标运动
Hideharu Miura1,2, Masao Tanooka3, Soichiro Ishihara1
1Department of Radiation Oncology, Hiroshima High-Precision Radiotherapy Cancer Center, Hiroshima, JPN.
Cureus
|December 5, 2024
概括
矢量体积组图 (VVH) 软件使用可变形图像注册量化呼吸器官运动. 该工具准确地测量了目标位移,有助于为肺癌患者的治疗计划做出临床决策.
科学领域:
- 医疗成像医学成像
- 放射治疗 物理 物理
- 计算解剖学的计算解剖学
背景情况:
- 呼吸运动显著影响放射治疗的准确性.
- 对器官运动的定量评估对于有效的治疗计划至关重要.
研究的目的:
- 开发和评估向量体质图 (VVH) 软件,用于对呼吸器引起的器官运动进行体积定量评估.
- 使用可变形图像注册 (DIR) 来评估使用VVH的运动.
主要方法:
- 开发了VVH软件作为一个Python插件.
- 采用基于 B-spline 的 DIR 算法来计算变形向量场 (DVF).
- 使用移动幻影验证VVH并将其应用于肺癌患者的4DCT扫描.
主要成果:
- VVH准确地测量了幻象目标的位移 (例如,对于20毫米的转移,19,9毫米和19.6毫米).
- 在一个肺癌患者中,VVH量化了运动:1.9毫米 (LR),1.9毫米 (AP),18.8毫米 (CC) 和18.9毫米 (3D).
- 将VVH结果与中心子方法进行比较,突出显著的CC和3D运动 (13.5毫米).
结论:
- VVH软件提供了呼吸诱导的目标运动的体积定量评估.
- 该工具可以在放射治疗治疗计划期间为战略临床决策提供信息.
- VVH为评估4DCT成像中的器官运动提供了一种有价值的方法.
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