红细胞信号在Plasmodium入侵中被功能性地保存
James Jia Ming Yong1, Xiaohong Gao1, Prem Prakash1
1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
iScience
|December 5, 2024
概括
杆菌 (Plasmodium merozoite) 的入侵依赖于一个保存的宿主细胞信号通路. RH5-基因相互作用触发流入,对寄生虫入境至关重要,并可能成为新疗法的向.
科学领域:
- 疟疾学 疟疾学
- 细胞信号传输 细胞信号传输
- 传染性疾病 传染性疾病
背景情况:
- 在入侵过程中,Plasmodium merozoites与红细胞 (RBC) 受体相互作用.
- 红细胞信号传递在促进寄生虫进入中的作用尚不清楚.
- 众所周知,Plasmodium falciparum可以操纵红细胞 (Ca2+) 信号传输.
研究的目的:
- 调查红细胞Ca2+流入在不同物种间的Plasmodium入侵中所起的保护作用.
- 为了阐明由 merozoite 配体-受体相互作用触发的信号通路.
- 为了确定潜在的治疗目标,以阻止寄生虫入侵.
主要方法:
- 研究了红细胞Ca2+流入在使用各种类型的Plasmodium入侵中的作用.
- 研究了RH5-基因相互作用对红细胞信号通路的影响.
- 在入侵期间利用抑制剂阻断RBC信号通路.
- 分析了红细胞膜蛋白复合体协会中的变化.
主要成果:
- 在Plasmodium入侵中证明了对红细胞Ca2+流入的保留要求.
- 显示RH5-基因相互作用触发RBC循环腺单酸盐 (cAMP) 的增加.
- 证实cAMP的增加促进了Ca2+的流入,这对于入侵至关重要.
- 确定RH5-基因结合会诱导涉及β-上腺体受体的多重RBC膜复合体.
- 向这些红细胞信号通路的抑制剂阻断了Plasmodium的入侵.
结论:
- 保存的宿主cAMP-Ca2+信号级联对于等离子体入侵至关重要.
- 这种信号通路是由RH5-基因相互作用触发的,涉及RBC膜复杂重组.
- 针对这种保存的宿主信号通路提供了一种有前途的抗疟疾治疗策略.
相关概念视频
Intracellular Signaling Affects Focal Adhesions
2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.6K
Symbiosis
27.4K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.4K
Diversity of Protists II
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Formation of the Platelet Plug
4.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
4.4K
Contact-dependent Signaling
44.4K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
44.4K
Cell Signaling in Plants
5.6K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.6K


