在卷紧缩过程中弹性回收的动力学
Martin Lück1, Stefan Klinken-Uth1, Peter Kleinebudde1
1Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Düsseldorf, Germany.
International journal of pharmaceutics: X
|December 5, 2024
概括
卷紧缩中的弹性回收被使用直线测量来研究. 增加的压缩力加快了恢复速度,而滚动速度的影响最小,除非存在脆性填充剂.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 弹性回收在平板时至关重要,但在卷积压缩方面没有充分研究.
- 现有的关于卷积压缩中的弹性回收的数据是有限的.
- 卷紧缩是制药制造中的一个关键过程.
研究的目的:
- 为了研究卷紧缩过程中弹性回收的动力学.
- 为了确定压缩力和滚动速度对弹性恢复的影响.
- 为了描述卷紧缩中的放松时间.
主要方法:
- 使用直线激光三角测量技术进行测量.
- 在滚筒旋转和随时间推移的不同位置测量弹性回收.
- 分析了纯微晶纤维素和两个安慰剂粉末混合物.
主要成果:
- 弹性恢复动力学是使用两个指数函数建模的:一个快速和一个缓慢的阶段.
- 增加的压缩力加速了快速和缓慢的弹性恢复阶段.
- 滚动速度仅在包含脆性填充剂时才会影响弹性回收动力学.
结论:
- 建立了卷积压缩中的弹性回收的第一个动态表征.
- 证明了压缩力对弹性回收的显著影响.
- 突出了材料特性 (脆性填充剂) 在调节滚卷紧缩行为的作用.
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