在患有自闭症谱系障碍的儿童中,特定于子区域的甲状腺皮层功能连接,执行功能和社会行为
Jasmine Si Min Chuah1, Aisleen M A Manahan1, Shi Yu Chan1
1Agency for Science, Technology and Research, Institute for Human Development and Potential (IHDP), Singapore, Singapore.
概括
在患有自闭症谱系障碍 (ASD) 的儿童中,皮层功能连接的改变与社会行为缺陷有关. 认知灵活性和情绪控制调解了这种关系,表明了潜在的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 丘陵体是认知功能,包括社会行为,由于其广泛的皮层连接的关键枢纽.
- 静止状态功能连接 (RSFC) 改变在甲状腺皮层网络与神经发育障碍有关.
- 对于患有自闭症谱系障碍 (ASD) 的儿童来说,了解胸膜皮层RSFC,执行功能和社会行为之间的相互作用至关重要.
研究的目的:
- 调查与没有ASD的儿童的thalamocorticalRSFC和社会行为之间的关联.
- 检查执行功能 (EF) 亚域在患有自闭症儿童的甲状腺皮层RSFC和社会行为之间的关系中扮演的调解角色.
- 确定与ASD社会沟通和互动 (SCI) 最相关的特定的thalamic子区域和EF领域.
主要方法:
- 利用来自自闭症脑成像数据交换 (ABIDE) 倡议的神经成像和行为数据,用于儿童 (年龄<14岁).
- 雇员斯皮尔曼的等级相关性来评估thalamocorticalRSFC和社会反应量表 (SRS) 的社会沟通和互动 (SCI) 评分之间的关联.
- 进行了调解分析,以评估8个EF子域在ASD儿童中的作用 (n=139).
主要成果:
- 在自闭症儿童的RSFC和SCI分数 (ρ=0.23,pFDR=0.012) 中发现了右丘脑默认模式网络 (DMN) RSFC和SCI分数之间的显著关联.
- 这种关联主要由中枢,腹腔和内膜下子区域驱动.
- 认知灵活性 (ACME=0.13,p=0.016) 和情绪控制 (ACME=0.08,p=0.020) 显著介导了右丘脑-DMN RSFC和SCI分数之间的联系.
结论:
- 甲状腺皮层RSFC,特别是涉及右甲状腺和DMN,与ASD儿童的社会行为缺陷有显著的关联.
- 认知灵活性和情绪控制成为关键调解者,突出显示它们在大脑与行为关系中的重要性.
- 这些发现提供了精确的大脑行为映射,并建议认知灵活性和情绪调节作为潜在的治疗目标,以改善ASD的社会结果.
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